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Nevertheless, it remains unclear whether cystine starvation in the TME triggers T-cell ferroptosis and impairs anti-tumor immunity

250-500

The pharmacokinetic and toxicity properties of the lead compounds (CB-27, CB-41, CB-50, CB-53, CB-58, CB-59, and CB-61) were compared to CQ (Supplementary Table S6)

Ciprofloxacin powder (MilliporeSigma 17850) was dissolved in dilute acid (0.1 M HCl)

These samples assisted in identifying baseline FOXO4 expression patterns and age-related changes in Leydig cells, with all procedures strictly adhering to ethical guidelines and informed consent protocols [2]

Abstract Erastin, which has been initially identified as a synthetic lethal compound against cancer expressing an RAS oncogene, inhibits cystine/glutamate antiporters and causes ferroptic cell death in various cell types, including therapy-resistant mesenchymal cancer cells